人胃肠道间质瘤细胞GIST882

细胞名称

人胃肠道间质瘤细胞GIST882

货物编码

BFN60808731

产品规格

T25培养瓶x1

1.5ml冻存管x2

细胞数量

1x10^6

1x10^6

保存温度

37℃

-198℃

运输方式

常温保温运输

干冰运输

安全等级

1

用途限制

仅供科研     3类

培养体系

DMEM高糖+10%FBS+1%三抗

培养温度

37℃

二氧化碳浓度

5%

简介

人胃肠道间质瘤细胞GIST882取自女性供体。

注释

倍增时间34h

基因突变

Homozygous for KIT p.Lys642Glu (c.1924A>G) (PubMed=11526490; PubMed=16077968).

HLA信息

STR信息

参考文献

PubMed=11526490; DOI=10.1038/sj.onc.1204704

Tuveson D.A., Willis N.A., Jacks T., Griffin J.D., Singer S., Fletcher C.D.M., Fletcher J.A., Demetri G.D.

STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications.

Oncogene 20:5054-5058(2001)

PubMed=16077968; DOI=10.3892/or.14.3.645

Noma K., Naomoto Y., Gunduz M., Matsuoka J., Yamatsuji T., Shirakawa Y., Nobuhisa T., Okawa T., Takaoka M., Tomono Y., Hiroyuki O., Gunduz E., Tanaka N.

Effects of imatinib vary with the types of KIT-mutation in gastrointestinal stromal tumor cell lines.

Oncol. Rep. 14:645-650(2005)

PubMed=16982758; DOI=10.1158/0008-5472.CAN-06-0165

Bauer S., Yu L.K., Demetri G.D., Fletcher J.A.

Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor.

Cancer Res. 66:9153-9161(2006)

PubMed=19706776; DOI=10.1158/0008-5472.CAN-08-4004

Muhlenberg T., Zhang Y., Wagner A.J., Grabellus F., Bradner J., Taeger G., Lang H., Taguchi T., Schuler M., Fletcher J.A., Bauer S.

Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.

Cancer Res. 69:6941-6950(2009)